Great Danes are considered to be a Giant breed dog as they weigh over 50kg and as they are more prone to skeletal and joint problems they need to be fed a diet that helps to support healthy joints and also helps protect against the signs of premature aging. Science Plan Canine Active Longevity Mature Adult Large Breed contains the Superior Antioxidant Formula to help protect the immune system and helps maintain joint health and inflammation. L-Carnitine is also present to help control body weight and therefore helps to minimise stress on the joints.